Over the summer we filed a Freedom of Information Request with the US Food and Drug Administration to obtain the toxicology studies filed by the manufacturer of Tinuvin® 770 in order to get it approved to be an additive in adhesives and pharmaceutical-grade plastics. Most of the documents are from 1975-76.

We received the tranche of documents on September 10, 2024. While almost all are animal studies, there is way more information than in the academic literature. (Which is why we always caution against drawing inferences from what little leaks from industry to scientific journals.) We are posting all the documents we received here without comment so our community can learn from them.

Summary of Safety

This is the Summary of Safety information submitted by the manufacturer in 1976. These tables summarize the the studies in PDFs that follow.

Cardiac Tissue

This was as a surprising conclusion to me:

Specific Toxicity Studies

Acute Oral Toxicity to Rats

Acute Dermal LD50 in Rat

Acute Dust Inhalation Toxicity and Acute Vapor Inhalation Toxicity Society

Acute Vapor Inhalation Toxicity in Albino Rats

Acute Dust Toxicity

Acute Vapor Inhalation Toxicity

Skin Irritation, Sensitization, Phototoxicity

Acute Eye Irritation

Human Skin "Repeated Insult"

Salmonella/Mammalian Mutagenicity

Dietary Toxicity

FDA Review as Food Adhesive

Review of studies by FDA in August 1998 for the use of Tinuvin® 770 as an adhesive for food.